Bipolar Disorder

Ketogenic diet as a metabolic treatment for mental illness

is important that researchers and clinicians are made aware of the trajectory of the evidence for the implementation of ketogenic diets in mental illnesses, as such a metabolic intervention provides not only a novel form of symptomatic treatment, but one that may be able to directly address the underlying disease mechanisms and, in so doing, also treat burdensome comorbidities. 

The ketogenic diet for type II bipolar disorder

Two women with type II bipolar disorder were able to maintain ketosis for prolonged periods of time... Both experienced mood stabilization that exceeded that achieved with medication; experienced a significant subjective improvement that was distinctly related to ketosis... These cases demonstrate that the ketogenic diet is a potentially sustainable option for mood stabilization in type II bipolar illness. 

Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: a systematic review of the literature

Bipolar disorder and inflammation are linked through shared genetic polymorphisms and gene expression as well as altered cytokine levels...Several conventional mood stabilizers have anti-inflammatory properties...Inflammation is closely linked with behavioral parameters such as exercise, sleep, alcohol abuse, and smoking, as well as with medical comorbidities including coronary artery disease, obesity and insulin resistance, osteoporosis, and pain.

Multinutrient supplement as treatment: literature review and case report of a 12-year-old boy with bipolar disorder.

This article examines a case study of a 12-year-old boy with bipolar disorder and co-morbid diagnoses treated for 6 years with conventional medication and finally a multinutrient supplement...After 6 years of conventional treatment, he received 14 months of [multinutrient supplement] which resulted in outcome superior to conventional treatment.

Ketosis and bipolar disorder: controlled analytic study of online reports

Researchers undertook an observational analytic study of free-text comments in online forums about mood effects of dietary interventions (ketogenic, omega-3 enriched or vegetarian) classified by a priori categories of change in mood stabilization in 274 people with bipolar disorder. Reports of significant mood stabilization or remission of symptoms over a period were substantially higher for a ketogenic diet than for other diets.

Ketogenic diet as a metabolic therapy for mood disorders: Evidence and developments

Preclinical studies, case reports, and case series have demonstrated antidepressant and mood-stabilizing effects of KD, however, to date, no clinical trials for depression or bipolar disorder have been conducted. Because of its potential pleiotropic benefits, KD should be considered as a promising intervention in research in mood disorder therapeutics, especially in treatment-resistant presentations.

The Ketogenic Diet May Have Mood-Stabilizing Properties

The ketogenic diet may stabilize mood in bipolar illness. Several anticonvulsant interventions may improve outcome in mood disorders. Furthermore, beneficial changes in brain-energy profile are noted in subjects on the ketogenic diet. Finally, the extracellular changes that occur in ketosis would be expected to decrease intracellular sodium concentrations, a common property of all effective mood stabilizers. 

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