An overview of links between obesity and mental health
This review examines the overlap between mental illness and comorbid obesity highlighting clinical and biological factors that have been linked to this association in order to improve our understanding and help elucidate potential therapeutic avenues.
A randomized, placebo‐controlled crossover trial of phentermine‐topiramate ER in patients with binge‐eating disorder and bulimia nervosa
This first randomized control trial to evaluate the efficacy and safety of PHEN/TPM‐ER for BED/BN found this drug combination significantly more effective at reducing binge eating than placebo and was well-tolerated.
Which foods may be addictive? The roles of processing, fat content, and glycemic load
This cross-sectional study provides preliminary evidence that not all foods are equally implicated in addictive-like eating behavior, and highly processed foods, which may share characteristics with drugs of abuse (e.g. high dose, rapid rate of absorption) appear to be particularly associated with "food addiction."
Food addiction, high-glycemic-index carbohydrates, and obesity
This review proposes that food addiction is a plausible etiological factor contributing to the heterogeneous condition and phenotype of obesity. In at least a subset of vulnerable individuals, high-glycemic-index carbohydrates trigger addiction-like neurochemical and behavioral responses.
Obese adolescents with eating disorders: Analysis of metabolic and inflammatory states
This study compared effect of interdisciplinary therapy on the physical and metabolic profiles, including body composition, insulin resistance and sensitivity as well as adiponectin and leptin concentrations, of obese adolescents with and without eating disorder symptoms.
Inflammatory cytokines and anorexia nervosa: A meta-analysis of cross-sectional and longitudinal studies
Despite abnormally low BMI, Anorexia Nervosa (AN) seems to be associated with increased inflammatory cytokines. Whether specific elevated cytokines represent trait or state markers of AN, and whether they could be treatment targets requires further study.
Anorexia nervosa and the immune system—a narrative review
Research is suggestive of increased levels of various pro-inflammatory cytokines as well as the spontaneous production of tumor necrosis factor in anorexia nervosa; genetic studies further support a dysregulated immune system in this disorder.
Brain-Behavior-Immune Interaction: Serum Cytokines and Growth Factors in Patients with Eating Disorders at Extremes of the Body Mass Index (BMI) Spectrum
For the first time, IL-1α, IL-10, EGF, and IFN-γ were shown to differ between patients with anorexia nervosa and healthy controls, and between patients with anorexia and individuals with obesity with or without binge-eating disorder.
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder.
Ultra-processed foods and binge eating: A retrospective observational study
There is increasing evidence of the impact of ultra-processed foods on multiple metabolic and neurobiological pathways, including those involved in eating behaviors, both in animals and in humans. This study explored ultra-processed foods and their link with disordered eating in a clinical sample.