Depression + Anxiety

The antidepressant properties of the ketogenic diet

Rats on the ketogenic diet spent less time immobile, suggesting that rats on the ketogenic diet, like rats treated with antidepressants, are less likely to exhibit 'behavioral despair.'

Role of Interleukin-6 in Depressive Disorder

Rats on the ketogenic diet spent less time immobile, suggesting that rats on the ketogenic diet, like rats treated with antidepressants, are less likely to exhibit 'behavioral despair.'

Gestational ketogenic diet programs brain structure and susceptibility to depression & anxiety in the adult mouse offspring

The adult ketogenic diet offspring exhibit reduced susceptibility to anxiety and depression, and elevated physical activity level when compared with controls exposed to the Standard Diet both in utero and postnatally. Many neuro‐anatomical differences exist between the KD offspring and controls, including, for example, a cerebellar volumetric enlargement.

Dietary pattern and depressive symptoms in middle age

In middle-aged participants, a processed food dietary pattern is a risk factor for depression 5 years later, whereas a whole food pattern is protective.

The association between dietary patterns and mental health in early adolescence

Findings implicate a Western dietary pattern in poorer behavioural outcomes for adolescents. Better behavioural outcomes were associated with a higher intake of fresh fruit and leafy green vegetables.

Dietary fat intake and the risk of depression: the SUN project

A detrimental relationship was found between trans unsaturated fat intake and depression risk, whereas weak inverse associations were found for MUFA, PUFA and olive oil. These findings suggest that cardiovascular disease and depression may share some common nutritional determinants related to subtypes of fat intake.

Mediterranean dietary pattern and prevalence and incidence of depressive symptoms in mid-aged women: results from a large community-based prospective study

Consumption of a 'Mediterranean-style' dietary pattern by mid-aged women may have a protective influence against the onset of depressive symptoms.

Sugar intake from sweet food and beverages, common mental disorder and depression: prospective findings from the Whitehall II study

Aim of this study was to investigate associations between sweet food/beverage intake, common mental disorder and depression and to examine the role of reverse causation (influence of mood on intake) as potential explanation for the observed linkage. This study confirms an adverse effect of sugar intake on long-term psychological health.

Efficacy of omega-3 PUFAs in depression: a meta-analysis

Researchers conducted meta-analysis of double-blind randomized placebo-controlled trials to estimate the efficacy of omega-3 polyunsaturated fatty acids (PUFAs), especially docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), in the improvement of depression...Current evidence supports the finding that omega-3 PUFAs with EPA ≥ 60% at a dosage of ≤1 g/d would have beneficial effects on depression.

A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial)

'SMILES’ was a 12-week, parallel-group, single blind, randomised controlled trial of an adjunctive dietary intervention in the treatment of moderate to severe depression...Results indicate that dietary improvement may provide an efficacious and accessible treatment strategy for the management of this highly prevalent mental disorder.

Association of Western and traditional diets with depression and anxiety in women

This study examined the extent to which the high-prevalence mental disorders are related to habitual diet in women. A 'traditional' dietary pattern characterized by vegetables, fruit, meat, fish, and whole grains was associated with lower odds for major depression or dysthymia and for anxiety disorders. A 'western' diet of processed or fried foods, refined grains, sugary products, and beer was associated with greater psychological symptoms.

Fish consumption and depression: the Northern Finland 1966 birth cohort study

"Since low fish consumption and omega-3 fatty acids have recently been linked with depression, we investigated...whether a low fish consumption is associated with increased risk of developing depression. A low frequency of fish consumption was statistically significantly associated with depression in women, but not in men

Vegetarian diets and depressive symptoms among men

Self-report data indicates vegetarian men have more depressive symptoms after adjustment for socio-demographic factors. Nutritional deficiencies (e.g. in cobalamin or iron) are a possible explanation for these findings.

Red meat consumption and mood and anxiety disorders

In this study, we report that women habitually consuming less than the recommended intake of red meat were more likely to have a diagnosed depressive or anxiety disorder than those consuming the recommended amount. Moreover, those consuming more than the recommended amount of red meat were also more likely to have a depressive disorder once overall diet quality was taken into account.

Inflammatory dietary pattern and risk of depression among women

This is a prospective analysis of the relationship of this pattern and depression risk among participants in the Nurses’ Health Study...The inflammatory dietary pattern is associated with a higher depression risk. This finding suggests that chronic inflammation may underlie the association between diet and depression.

Associations of depression with C-Reactive Protein, IL-1, and IL-6: a meta-analysis

This study aimed to assess the magnitude and direction of associations of depression with C-reactive protein (CRP), interleukin (IL)-1, and IL-6 in community and clinical samples. Researchers found that depression and CRP, IL-1, and IL-6 are positively associated and BMI is a mediating/moderating factor. A dose-response relationship between depression and these inflammatory markers may exist. 

The inflammatory potential of the diet Is associated with depressive symptoms in different subgroups of the general population

The promotion of a healthy diet with anti-inflammatory properties may help to prevent depressive symptoms, particularly among men, smokers, or physically inactive individuals. 

Meat and mental health: a systematic review of meat abstention and depression, anxiety, and related phenomena

This review examines the relation between the consumption or avoidance of meat and psychological health and well-being.

Roles of Inflammation and Depression in the Development of Gestational Diabetes

The relationship between inflammation and depression is less defined among perinatal women. Perinatal depression may be a heterogeneous construct, and that inflammation may be relevant to it in the context of other inflammatory morbidities of pregnancy.

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